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St. John's Wort (hypericum) is used for depression or anxiety that leads to fatigue and adrenal gland exhaustion. It appears to work at least in part as an SRI (Serotonin Reuptake Inhibitor). Combining an SRI with an MAO inhibitor can produce a dangerous rise in blood pressure; after stopping use of MAO inhibitors, one should wait four weeks before taking any SRIs. Until further research is done on how and why hypericum works to alleviate the symptoms of depression, hypericum should be considered an SRI and treated accordingly.
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