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A 2001 study showed that a lifetime of marijuana smoking was not associated with deficits in general intellectual function, abstraction ability, sustained attention, verbal fluency or ability to learn and recall new verbal and visuospatial. information after one month of abstinence. This was a controlled study of 180 volunteers including 63 heavy marijuana users (who had smoked cannabis at least 5,000 times in their lives), all smoking daily at the start of the study; 45 former heavy users who had smoked no more than 12 times in the previous three months; and 72 control subjects who had smoked no more than 50 times in their lives. Recall of word lists was reduced in heavy users who smoked daily at entry into the study only during the first week of abstinence. Aggression, anger, irritability, restlessness and strange dreams increased significantly only during one of the abstinence phases. [Arch Gen Psychiatry 2001;58(10): pp.917-24].
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