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Tripterygium wilfordii Hook F is a plant of the genus Tripterygium of the family celastraceae. Many preparations, mainly from its root, have been used clinically, among which the polyglycoside (TP) has shown better effects. Many side-effects, however, have been reported. In female patients treated with TP, reduction of menses was noted 4 weeks after initiation of therapy, and amenorrhea was observed in 30% and 90% of the cases respectively 3 months after and 6 months after starting use of the extract. In general, the longer the duration of administration and the older the patients, the smaller the probability of their menses or sperm returning to normal.
Frequent upper abdominal pain, nausea and reduced appetite were also reported, and impairment of hepatic and renal functions appeared in a few cases.
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