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Relatively pure PC supplements are generally labeled as “phosphatidylcholine”. PC best duplicates supplements used in medical research. Choline by itself (without the “phosphatidyl” group) is also available in foods and supplements. Choline is now considered an essential nutrient, needed for cell membrane integrity and to facilitate the movement of fats in and out of cells. For this reason, PC has been used in a number of preliminary studies for a wide variety of neurological and psychiatric disorders [Benjamin J, Levine J, Fux M, et al. Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder. Am J Psychiatry 1995;152: pp.1084-6.], though not every study suggests that supplemental choline is capable of reaching the brain [Dechent P, Pouwels PJW, Frahm J. Neither short-term nor long-term administration of oral choline alters metabolite concentrations in human brain. Biol Psychiatry 1999;46: pp.406-11].
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