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PMS-C is associated with increased appetite, craving for sweets, headache, fatigue, fainting spells, and heart palpitations. Glucose tolerance tests (GTT) performed on PMS-C patients during the luteal phase of their cycle show a flattening of the early part of the curve, whereas during the follicular phase (first half of cycle) their GTT is normal. Some studies have also shown a fourth-hour hypoglycemic response during the luteal phase. This appears to be hormonally regulated, but other factors may also be involved. For example, the cellular response to a high glucose load results in an increased affinity for insulin. All are possible mechanisms. A deficiency of the prostaglandin PGE, in the pancreas and CNS may also be involved in PMS-C. PGE1 inhibits glucose induced insulin secretion in humans.
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