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Standard liver enzyme blood tests may or may not be elevated in such cases. Phase I detoxification rates that are in excess of phase II activity will also cause toxicity problems due to excessive accumulation of activated intermediates. Clearance tests using saliva, urine, and/or blood after chemical challenge by caffeine, aspirin, and acetaminophen can be useful in detecting Phase I and II imbalances. Other causes include viral infections of the liver, some inherited disorders such as Gilbert's syndrome, alcohol-induced fatty deposits, the use of anabolic steroids/estrogens/oral contraceptives and hyperthyroidism.
Bile flow can be restricted also by extrahepatic means such as gallstones, pregnancy, or other physical causes such as tumors. Among the other symptoms, people with a sluggish liver may complain of depression, general malaise, headaches, digestive disturbances, allergies and chemical sensitivities, premenstrual syndrome, and constipation. |
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