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Infectious mononucleosis is fairly common and both sexes are affected equally; prognosis is excellent, and major complications are uncommon. When such an illness lasts more than 6 months, it is frequently called chronic EBV infection. However, the laboratory tests for EBV are for the most part accurate and specific. In most cases, a distinction can be made as to whether a person is susceptible to EBV, has had a recent infection, has had infection in the past, or has a reactivated EBV infection. When the "mono spot" test is negative, the optimal combination of EBV serologic testing consists of the antibody titration of four markers: IgM and IgG to the viral capsid antigen, IgM to the early antigen, and antibody to EBNA. IgM to the viral capsid antigen appears early in infection and disappears within 4 to 6 weeks.
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