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Hyperplasia usually develops in the presence of continuous estrogen stimulation unopposed by progesterone. During adolescence and in the years before menopause women may have numerous cycles without ovulation during which there is continuous unopposed estrogen activity. Similarly, hormone replacement therapy consisting of estrogen without progesterone may lead to endometrial hyperplasia. By microscopic exam it can be determined if hyperplasia with or without atypical cells is present. Hyperplasia without atypia rarely progresses to endometrial cancer while hyperplasia with atypia is a precancerous condition that may progress to overt malignancy.
Endometrial hyperplasia is currently the reason for 5% of all hysterectomies performed in the U.S. Conventional medicine uses progestins such as Provera, given continuously, either by mouth or long acting injections.
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